5/16/2025
Last update
5/16/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
9
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
9
We examined the effects of pyridoxamine, a vitamin B6 derivative, on heart damage caused by doxorubicin (DOX), a common chemotherapy drug known for its harmful impact on the heart. In our study, we used a rat model where some rats received DOX while others received a combination of DOX and pyridoxamine. We also included control groups for comparison to ensure the effectiveness of the treatment could be clearly evaluated.
Our findings showed that pyridoxamine significantly reduced the heart-related harm often associated with DOX treatment. Specifically, it helped in preserving the heart's structure and function, limiting the development of conditions like dilated cardiomyopathy. Furthermore, pyridoxamine appeared to mitigate inflammation, fibrosis, and oxidative stress, all of which can worsen heart health over time.
The treatment notably protected against iron-related cell death, restoring healthier balance in iron levels and improving overall heart condition at the genetic level. This suggests that pyridoxamine could serve as a promising new strategy to protect against heart damage in patients undergoing chemotherapy.
Our findings showed that pyridoxamine significantly reduced the heart-related harm often associated with DOX treatment. Specifically, it helped in preserving the heart's structure and function, limiting the development of conditions like dilated cardiomyopathy. Furthermore, pyridoxamine appeared to mitigate inflammation, fibrosis, and oxidative stress, all of which can worsen heart health over time.
The treatment notably protected against iron-related cell death, restoring healthier balance in iron levels and improving overall heart condition at the genetic level. This suggests that pyridoxamine could serve as a promising new strategy to protect against heart damage in patients undergoing chemotherapy.
Read More
8
We explored the potential of vitamin B6 (VB6) to boost heart recovery following acute myocardial infarction (AMI). Our research focused on how VB6 might promote angiogenesis, which is the process of forming new blood vessels, a crucial factor for improving heart function after a heart attack.
To investigate this, we conducted experiments measuring the effects of VB6 on human umbilical vein endothelial cells, a type of cell involved in blood vessel formation. We noticed that VB6 not only increased cell migration and tubule formation but also activated AMP-activated protein kinase (AMPK), a key player in cellular energy regulation. This activation led to a positive chain reaction that enhanced the production of vascular endothelial growth factor A, which aids in blood vessel growth.
Perhaps most exciting is our finding from in vivo studies, where long-term VB6 supplementation in mice significantly improved heart functions, increased new blood vessel formation, and reduced inflammatory cytokines after AMI. This suggests that VB6 serves as a strong ally in promoting heart recovery after ischemic injury. Our results indicate that adding VB6 to treatment plans could be beneficial in preventing cardiac dysfunction following heart attacks.
To investigate this, we conducted experiments measuring the effects of VB6 on human umbilical vein endothelial cells, a type of cell involved in blood vessel formation. We noticed that VB6 not only increased cell migration and tubule formation but also activated AMP-activated protein kinase (AMPK), a key player in cellular energy regulation. This activation led to a positive chain reaction that enhanced the production of vascular endothelial growth factor A, which aids in blood vessel growth.
Perhaps most exciting is our finding from in vivo studies, where long-term VB6 supplementation in mice significantly improved heart functions, increased new blood vessel formation, and reduced inflammatory cytokines after AMI. This suggests that VB6 serves as a strong ally in promoting heart recovery after ischemic injury. Our results indicate that adding VB6 to treatment plans could be beneficial in preventing cardiac dysfunction following heart attacks.
Read More
Most Useful Reviews
9
Supports cardiovascular health
Nature's Way Vitamin B6 is a key supplement for various bodily functions, including amino acid metabolism and nerve system support. It aids in neurotransmitter production, which impacts mood and cognition, while also supporting hemoglobin formation. Additionally, it helps lower homocysteine levels, potentially reducing the risk of cardiovascular disease. This supplement boosts energy, improves cognitive function, and reduces stress.
Read More
6
Promising alternative treatment
4 people found this helpful
I could not find a direct analogue of Milgamma Compositum, but I discovered excellent substitutes containing benfotiamine and pyridoxine hydrochloride. These supplements, taken as advised, can effectively address neurological issues like thoracalgia, which my friend was prescribed for. B vitamins are known for their sedative properties, aiding in pain relief. These medications work best when combined with treatments like massage. I recommend this combination for managing cardiovascular disease and ensuring a better quality of life.
Read More
8
Prevention of diseases
Vitamin B6 plays a vital role in biochemical processes, regulating fat and protein exchange and maintaining cholesterol levels. Its deficiency can cause anaemia and adversely affect the cardiovascular system. Regular intake supports heart muscle function and helps prevent serious conditions such as thrombosis and hypertension. Overall, Vitamin B6 enhances immune response and plays a significant role in preventing cardiovascular disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8
- All Researches
9
We examined how vitamin B6, or pyridoxine, might help protect against cardiovascular issues, specifically focusing on its effects in a model of angina in rats. The study involved administering vasopressin, which induced heart stress and ischemia, helping us assess the protective capabilities of pyridoxine.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
Read More
9
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
9
We set out to understand whether vitamin B-6 has preventive effects on heart failure with preserved ejection fraction (HFpEF), a condition often associated with changes in heart macrophages. To test this, we used a mouse model where we induced HFpEF through a combination of a high-fat diet and a specific supplement.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
Read More
9
Vitamin B6 shows uncertain cardiovascular effects
We conducted a study to assess the potential benefits of vitamin B6, along with other B vitamins, in lowering homocysteine levels and reducing bad cholesterol (LDL-C) in individuals at risk for cardiovascular disease due to specific genetic polymorphisms.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Read More
9
We investigated the potential of pyridoxamine, a derivative of vitamin B6, to protect the heart from the effects of doxorubicin, a common chemotherapy drug associated with heart problems. In this study, we treated Sprague Dawley rats with doxorubicin and monitored their heart function over eight weeks. We also administered pyridoxamine to some of the rats to see if it could counteract the drug’s harmful effects.
Our findings revealed that pyridoxamine significantly improved heart function in the rats treated with doxorubicin. Specifically, the left ventricular ejection fraction, which indicates how well the heart pumps blood, was notably higher in rats receiving pyridoxamine. Additionally, we found that pyridoxamine reduced the heart's end-systolic volume, suggesting it helped maintain heart health during doxorubicin treatment.
On the other hand, when we looked at the effects of doxorubicin on cancer cells in the lab, pyridoxamine did not change the drug's effectiveness. Doxorubicin still reduced cell viability and increased cell death in the tumor cells, which indicates that while pyridoxamine may protect the heart, it does not interfere with the drug's ability to fight cancer.
In conclusion, pyridoxamine appears to be a promising option for safeguarding heart health during cancer treatments with doxorubicin, without affecting the drug's anticancer properties.
Our findings revealed that pyridoxamine significantly improved heart function in the rats treated with doxorubicin. Specifically, the left ventricular ejection fraction, which indicates how well the heart pumps blood, was notably higher in rats receiving pyridoxamine. Additionally, we found that pyridoxamine reduced the heart's end-systolic volume, suggesting it helped maintain heart health during doxorubicin treatment.
On the other hand, when we looked at the effects of doxorubicin on cancer cells in the lab, pyridoxamine did not change the drug's effectiveness. Doxorubicin still reduced cell viability and increased cell death in the tumor cells, which indicates that while pyridoxamine may protect the heart, it does not interfere with the drug's ability to fight cancer.
In conclusion, pyridoxamine appears to be a promising option for safeguarding heart health during cancer treatments with doxorubicin, without affecting the drug's anticancer properties.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports cardiovascular health
Nature's Way Vitamin B6 is a key supplement for various bodily functions, including amino acid metabolism and nerve system support. It aids in neurotransmitter production, which impacts mood and cognition, while also supporting hemoglobin formation. Additionally, it helps lower homocysteine levels, potentially reducing the risk of cardiovascular disease. This supplement boosts energy, improves cognitive function, and reduces stress.
Read More
6
Promising alternative treatment
4 people found this helpful
I could not find a direct analogue of Milgamma Compositum, but I discovered excellent substitutes containing benfotiamine and pyridoxine hydrochloride. These supplements, taken as advised, can effectively address neurological issues like thoracalgia, which my friend was prescribed for. B vitamins are known for their sedative properties, aiding in pain relief. These medications work best when combined with treatments like massage. I recommend this combination for managing cardiovascular disease and ensuring a better quality of life.
Read More
8
Prevention of diseases
Vitamin B6 plays a vital role in biochemical processes, regulating fat and protein exchange and maintaining cholesterol levels. Its deficiency can cause anaemia and adversely affect the cardiovascular system. Regular intake supports heart muscle function and helps prevent serious conditions such as thrombosis and hypertension. Overall, Vitamin B6 enhances immune response and plays a significant role in preventing cardiovascular disease.
Read More
7.5
Improved well-being
Vitamin B6 is essential for my nervous and cardiovascular systems. Since taking it upon my doctor's recommendation, I have experienced significant improvement in my overall health.
Read More
Frequently Asked Questions
7.5
Improved well-being
Vitamin B6 is essential for my nervous and cardiovascular systems. Since taking it upon my doctor's recommendation, I have experienced significant improvement in my overall health.
8
Prevention of diseases
Vitamin B6 plays a vital role in biochemical processes, regulating fat and protein exchange and maintaining cholesterol levels. Its deficiency can cause anaemia and adversely affect the cardiovascular system. Regular intake supports heart muscle function and helps prevent serious conditions such as thrombosis and hypertension. Overall, Vitamin B6 enhances immune response and plays a significant role in preventing cardiovascular disease.
9
Supports cardiovascular health
Nature's Way Vitamin B6 is a key supplement for various bodily functions, including amino acid metabolism and nerve system support. It aids in neurotransmitter production, which impacts mood and cognition, while also supporting hemoglobin formation. Additionally, it helps lower homocysteine levels, potentially reducing the risk of cardiovascular disease. This supplement boosts energy, improves cognitive function, and reduces stress.
6
Promising alternative treatment
4 people found this helpful
I could not find a direct analogue of Milgamma Compositum, but I discovered excellent substitutes containing benfotiamine and pyridoxine hydrochloride. These supplements, taken as advised, can effectively address neurological issues like thoracalgia, which my friend was prescribed for. B vitamins are known for their sedative properties, aiding in pain relief. These medications work best when combined with treatments like massage. I recommend this combination for managing cardiovascular disease and ensuring a better quality of life.
8
We aimed to understand how levels of Pyridoxal 5'-Phosphate (PLP), the active form of vitamin B6, relate to lipid profiles and potentially impact cardiovascular health. Using data from a large, population-based survey involving adults aged 20 and older, we conducted a thorough analysis of the relationships between PLP levels and cholesterol types, like LDL (bad) and HDL (good) cholesterol.
Our results showed that higher PLP levels were associated with lower levels of LDL cholesterol, suggesting that vitamin B6 might play a role in reducing the risk of cardiovascular issues. In fact, a single unit increase in PLP was linked to a significant decrease of around 17.7% in LDL cholesterol levels. Additionally, we found that PLP levels were positively correlated with HDL cholesterol levels, indicating that higher PLP could lead to an improvement in good cholesterol.
Notably, these associations seemed stronger in specific groups, such as diabetic individuals and those who abstain from alcohol. This points to a potential for vitamin B6 supplementation as a preventive measure against cardiovascular and metabolic diseases, particularly for those at higher risk. Overall, our findings illuminate vitamin B6 as a promising player in heart health discussions, particularly through its effects on cholesterol levels.
Our results showed that higher PLP levels were associated with lower levels of LDL cholesterol, suggesting that vitamin B6 might play a role in reducing the risk of cardiovascular issues. In fact, a single unit increase in PLP was linked to a significant decrease of around 17.7% in LDL cholesterol levels. Additionally, we found that PLP levels were positively correlated with HDL cholesterol levels, indicating that higher PLP could lead to an improvement in good cholesterol.
Notably, these associations seemed stronger in specific groups, such as diabetic individuals and those who abstain from alcohol. This points to a potential for vitamin B6 supplementation as a preventive measure against cardiovascular and metabolic diseases, particularly for those at higher risk. Overall, our findings illuminate vitamin B6 as a promising player in heart health discussions, particularly through its effects on cholesterol levels.
8
We explored the potential of vitamin B6 (VB6) to boost heart recovery following acute myocardial infarction (AMI). Our research focused on how VB6 might promote angiogenesis, which is the process of forming new blood vessels, a crucial factor for improving heart function after a heart attack.
To investigate this, we conducted experiments measuring the effects of VB6 on human umbilical vein endothelial cells, a type of cell involved in blood vessel formation. We noticed that VB6 not only increased cell migration and tubule formation but also activated AMP-activated protein kinase (AMPK), a key player in cellular energy regulation. This activation led to a positive chain reaction that enhanced the production of vascular endothelial growth factor A, which aids in blood vessel growth.
Perhaps most exciting is our finding from in vivo studies, where long-term VB6 supplementation in mice significantly improved heart functions, increased new blood vessel formation, and reduced inflammatory cytokines after AMI. This suggests that VB6 serves as a strong ally in promoting heart recovery after ischemic injury. Our results indicate that adding VB6 to treatment plans could be beneficial in preventing cardiac dysfunction following heart attacks.
To investigate this, we conducted experiments measuring the effects of VB6 on human umbilical vein endothelial cells, a type of cell involved in blood vessel formation. We noticed that VB6 not only increased cell migration and tubule formation but also activated AMP-activated protein kinase (AMPK), a key player in cellular energy regulation. This activation led to a positive chain reaction that enhanced the production of vascular endothelial growth factor A, which aids in blood vessel growth.
Perhaps most exciting is our finding from in vivo studies, where long-term VB6 supplementation in mice significantly improved heart functions, increased new blood vessel formation, and reduced inflammatory cytokines after AMI. This suggests that VB6 serves as a strong ally in promoting heart recovery after ischemic injury. Our results indicate that adding VB6 to treatment plans could be beneficial in preventing cardiac dysfunction following heart attacks.
4
We explored the relationship between vitamin B6 and cardiovascular health, particularly its role in stroke risk. Through a two-sample Mendelian randomization approach, we used genetic data to estimate how nutrient intake, including vitamin B6, might affect stroke outcomes.
Our findings revealed a concerning aspect of vitamin B6: its association with an increased risk of large-artery stroke. While it’s essential to note this association, we must interpret these results cautiously due to the limited number of genetic markers studied for vitamin B6.
Thus, while vitamin B6 was part of our evaluation, the evidence suggesting a harmful effect on cardiovascular events is not definitive. Further investigation is needed to clarify its role and determine if it should be a primary focus in stroke prevention efforts.
Our findings revealed a concerning aspect of vitamin B6: its association with an increased risk of large-artery stroke. While it’s essential to note this association, we must interpret these results cautiously due to the limited number of genetic markers studied for vitamin B6.
Thus, while vitamin B6 was part of our evaluation, the evidence suggesting a harmful effect on cardiovascular events is not definitive. Further investigation is needed to clarify its role and determine if it should be a primary focus in stroke prevention efforts.
8
We explored the relationship between Vitamin B6, along with Vitamins E and B12, and coronary heart disease (CHD) using data from the National Health and Nutrition Examination Survey (NHANES), covering the years 2003 to 2020. Our study included over 33,000 participants, where we meticulously analyzed various factors such as age, race, and health behaviors to understand how these vitamins impact heart health.
Our findings revealed that Vitamin E and B6 appeared to have a protective effect against CHD, while the connection with Vitamin B12 was minimal. Notably, the most significant benefits from Vitamin E and B6 were observed in specific groups—particularly among women, those with a BMI in the overweight range, and smokers. This suggests that certain populations may gain more from Vitamin B6 than others.
Overall, it seems that increasing our intake of Vitamin B6, especially for those at higher risk, could be a beneficial strategy in reducing the odds of developing coronary heart disease. However, factors like income and education also played a role in these outcomes, indicating that heart health is influenced by a complex interplay of vitamins and lifestyle choices.
Our findings revealed that Vitamin E and B6 appeared to have a protective effect against CHD, while the connection with Vitamin B12 was minimal. Notably, the most significant benefits from Vitamin E and B6 were observed in specific groups—particularly among women, those with a BMI in the overweight range, and smokers. This suggests that certain populations may gain more from Vitamin B6 than others.
Overall, it seems that increasing our intake of Vitamin B6, especially for those at higher risk, could be a beneficial strategy in reducing the odds of developing coronary heart disease. However, factors like income and education also played a role in these outcomes, indicating that heart health is influenced by a complex interplay of vitamins and lifestyle choices.
References
- Zhang RY, Chen Y, Yan XQ, Zhang Y, Zhou H, et al. Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study. Front Nutr. 2025;12:1545301. 10.3389/fnut.2025.1545301
- Al-Khawlani MA, Al-Madhagi WM, Sabati AM, ALomaisi SAMA, Al-Najar M. Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats. Naunyn Schmiedebergs Arch Pharmacol. 2025. 10.1007/s00210-025-03905-6
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. 10.1016/j.ejphar.2025.177413
- Lellig M, Rodríguez M, López-Baltanás R, Hermann J, Wollenhaupt J, et al. Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients?. J Intern Med. 2024;296:435. 10.1111/joim.20015
- Rafinezhad M, Kheirouri S, Abbasnezhad M, Alizadeh M. What Dietary Vitamins and Minerals Might Be Associated with Paraoxonase-1 Serum Levels in Patients with Coronary Artery Disease?. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04382-3
- Ren W, Li Y, Lu C, Liu S, Shao Y, et al. Comprehensive assessment on the association of dietary vitamins with all-cause and cardiovascular mortality among individuals with prediabetes: evidence from NHANES 1999-2018. Food Funct. 2024;15:10037. 10.1039/d4fo02893g
- Dong G, Xu W, Xu L. Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study. Nutrients. 2024;16. 10.3390/nu16172818
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. 10.1038/s41598-024-68413-8
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. 10.1016/j.tjnut.2024.08.006
- Pokushalov E, Ponomarenko A, Bayramova S, Garcia C, Pak I, et al. Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16111550
- Wang P, Huang J, Xue F, Abuduaini M, Tao Y, et al. Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly. Front Immunol. 2024;15:1354958. 10.3389/fimmu.2024.1354958
- Haesen S, Verghote E, Heeren E, Wolfs E, Deluyker D, et al. Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells. Cells. 2024;13. 10.3390/cells13020120
- Haesen S, Jager MM, Brillouet A, de Laat I, Vastmans L, et al. Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity. Antioxidants (Basel). 2024;13. 10.3390/antiox13010112
